Research
Internal Research
Outcomes of Neonatal Intrapartum Asphyxia in South Africa
Firdose Nakwa and her team summarised retrospective data on the outcomes of asphyxiated infants from a public tertiary hospital in South Africa. Many studies reporting on outcomes of neonates with Hypoxic Ischaemic Encephalopathy (HIE) managed with Therapeutic Hypothermia (TH), also called cooling, are conducted under controlled study conditions. Few report in settings where this intervention is offered as part of the standard of care, especially from LMICs. In this study, we report on short-term outcomes of neonates with moderate-to-severe HIE where TH was offered as part of the standard of care. The study was titled: Characteristics and outcomes of neonates with intrapartum asphyxia managed with therapeutic hypothermia in a public tertiary hospital in South Africa. They concluded that the only factor associated with mortality was severe encephalopathy.
A DATABASE OF GENES AND VARIANTS REPORTED IN NEONATAL ENCEPHALOPATHY WITH SUSPECTED HYPOXIC ISCHEMIC ENCEPHALOPATHY (NESHIE)
Megan Holborn and her team created a genetic database on hypoxic-ischaemic encephalopathy (HIE) and cerebral palsy (CP). The database organises public genetic information on hypoxic-ischaemic encephalopathy. This database also helps identify research gaps in hypoxic-ischaemic encephalopathy (HIE). Researchers can now focus on genes and variants specific to their needs using the database’s filter and search features. A better understanding of what role particular genes and their variants play in HIE and CP may also be possible in future research.
External Research
2022
ERYTHROPOIETIN TO NEWBORNS WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
Author(s): Yvonne W. Wu, M.D., M.P.H., Bryan A. and Comstock, M.S. et al.
2022
A DATABASE OF GENES AND VARIANTS REPORTED IN NEONATAL ENCEPHALOPATHY WITH SUSPECTED HYPOXIC ISCHEMIC ENCEPHALOPATHY (NESHIE)
Author(s): Megan A. Holborn, Graeme Ford, Sarah Turner, Juanita Mellet, Jeanne van Rensburg, Fourie Joubert, Michael S. Pepper
2022
PAIN AND SEDATION MANAGEMENT DURING COOLING
Author(s): Bäcke P, Bruschettini M, Sibrecht G, Thernström Blomqvist Y, Olsson E
2022
IS COOLING BENEFICIAL FOR HIE BABIES?
Author(s): Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
2022
PAIN AND SEDATION MANAGEMENT DURING COOLING
Author(s): Bäcke P, Bruschettini M, Sibrecht G, Thernström Blomqvist Y, Olsson E
2021
COOLING FOR MODERATE OR SEVERE NEONATAL HIE INFANTS IN INDIA, SRI LANKA, AND BANGLADESH
Author(s): Sudhin Thayyil, Stuti Pant, Paolo Montaldo and Deepika Shukla et al.
2020
STEM CELL THERAPIES FOR HIE
Author(s): Bruschettini M, Romantsik O, Moreira A, Ley D, Thébaud B.
2012
MRI SCANS PREDICT BRAIN DAMAGE IN NEWBORNS
Author(s): Y. Cheong, MD; Lee Coleman, FRANZCR; Rod W. Hunt, PhD; Katherine J. Lee, PhD; Lex W. Doyle, MD; Terrie E. Inder, MD; Susan E. Jacobs, MD; for the Infant Cooling Evaluation Collaboration