Research

Internal Research

Outcomes of Neonatal Intrapartum Asphyxia in South Africa

Firdose Nakwa and her team summarised retrospective data on the outcomes of asphyxiated infants from a public tertiary hospital in South Africa. Many studies reporting on outcomes of neonates with Hypoxic Ischaemic Encephalopathy (HIE) managed with Therapeutic Hypothermia (TH), also called cooling, are conducted under controlled study conditions. Few report in settings where this intervention is offered as part of the standard of care, especially from LMICs. In this study, we report on short-term outcomes of neonates with moderate-to-severe HIE where TH was offered as part of the standard of care. The study was titled:  Characteristics and outcomes of neonates with intrapartum asphyxia managed with therapeutic hypothermia in a public tertiary hospital in South Africa. They concluded that the only factor associated with mortality was severe encephalopathy.

A DATABASE OF GENES AND VARIANTS REPORTED IN NEONATAL ENCEPHALOPATHY WITH SUSPECTED HYPOXIC ISCHEMIC ENCEPHALOPATHY (NESHIE)

Megan Holborn and her team created a genetic database on hypoxic-ischaemic encephalopathy (HIE) and cerebral palsy (CP). The database organises public genetic information on hypoxic-ischaemic encephalopathy. This database also helps identify research gaps in hypoxic-ischaemic encephalopathy (HIE). Researchers can now focus on genes and variants specific to their needs using the database’s filter and search features. A better understanding of what role particular genes and their variants play in HIE and CP may also be possible in future research.

External Research

2022

Author(s): Yvonne W. Wu, M.D., M.P.H., Bryan A. and Comstock, M.S. et al.

2022

Author(s): Megan A. Holborn, Graeme Ford, Sarah Turner, Juanita Mellet, Jeanne van Rensburg, Fourie Joubert, Michael S. Pepper

2022

Author(s): Bäcke P, Bruschettini M, Sibrecht G, Thernström Blomqvist Y, Olsson E

2022

Author(s): Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG

2022

Author(s): Bäcke P, Bruschettini M, Sibrecht G, Thernström Blomqvist Y, Olsson E

2021

Author(s): Sudhin Thayyil, Stuti Pant, Paolo Montaldo and Deepika Shukla et al.

2020

Author(s): Bruschettini M, Romantsik O, Moreira A, Ley D, Thébaud B.

2012

Author(s): Y. Cheong, MD; Lee Coleman, FRANZCR; Rod W. Hunt, PhD; Katherine J. Lee, PhD; Lex W. Doyle, MD; Terrie E. Inder, MD; Susan E. Jacobs, MD; for the Infant Cooling Evaluation Collaboration

2005

Author(s): Kecskes Z, Healy G, Jensen A.

2005

Author(s): Kecskes Z, Healy G, Jensen A.